I can probably just address this post directly to Mike Birbiglia since I know that he'll get a Google alert soon enough, and Mike (whose last name, even with concentrated effort, I have difficulty pronouncing correctly) let me assure you that this brief recommendation will not include any insults of your physique. In the hipster comedic universe, where the relatively unskinny Zack Galifinakis is the hottest man ever, I don't think you have anything to worry about anyways.
The one man show, Sleepwalk with Me, which many of you might recognize from the ubiquitous subway poster, is extremely charming and funny. Focusing on his own experiences with illness and an extreme sleep disorder that once had him jumping out of motel window in the middle of the night, the personal anecdotes speak to larger truths. I was laughing to the point of shaking several times, but be warned that the show is peppered with sudden emotionally poignant pitfalls that can even bring one to tears if, say you've had a few margaritas before entering the theater.
Playing at the intimate Bleeker Street Theater, we were able to get obstructed tickets for under $30 from Theater Mania but truthfully, the performance is well worth full price admission. Portions of the show have appeared on This American Life, but there's plenty of stuff you haven't heard on WBEZ.